The goal of the Lab is to develop new treatments and work towards a cure for epilepsy and other neurodevelopmental disorders using a range of innovative approaches in experimental systems.
The Lab studies mechanisms of cerebral cortical circuit function and circuit dysfunction in neurodevelopmental disorders. Investigators in the lab use mouse and human genetics, electrophysiology, pharmacology, imaging, optogenetics, and behavior, in a range of experimental model systems ranging from heterologous cells in culture, neurons generated from induced pluripotent stem (iPS) cells from human patients, and ex vivo and in vivo in animal models of human disease. The lab is particularly interested in the function of a prominent subtype of neuron known as the GABAergic inhibitory interneuron and the role of interneuron dysfunction as a cause of disease.
News from the Lab
Congrats, Jade!
Jade's paper in Cell Reports Medicine was featured in a Preview by Gerald Zamponi here: https://www.cell.com/cell-reports-medicine/pdf/S2666-3791(24)00048-X.pdf
Congrats, Melody!
Penn junior undergraduate Melody Cheng is recipient of the 2024 Meyerhoff Summer Fellowship for Neuroscience Research
Congrats, Zach!
Zach Rosenthal received a 1-Year $50K pilot grant from the Penn ITMAT Translational Biomedical Imaging Center (TBIC) entitled "Brain network dynamics in a rodent model of electroconvulsive therapy."