Penn PGY-3 Neurology Resident and recent NIH NINDS R25 recipient Evan Rosenberg published the magnum opus from his PhD! Evan shows that cannabidiol (CBD ) blocks the effects of an endogenous lipid (LPI) at the receptor GPR55, preventing LPI-mediated effects at both excitatory and inhibitory synapses that normally shift circuits towards hyperexcitability. He found that seizures promote the LPI-GPR55 pathway, creating a positive feedback loop that could promote future seizures. CBD, by blocking LPI-GPR55, interrupts this feedback loop, providing a potential mechanism of the anti-seizure actions of CBD.