The goal of the Lab is to develop new treatments and work towards a cure for epilepsy and other neurodevelopmental disorders using a range of innovative approaches in experimental systems.
The Lab studies mechanisms of cerebral cortical circuit function and circuit dysfunction in neurodevelopmental disorders. Investigators in the lab use mouse and human genetics, electrophysiology, pharmacology, imaging, optogenetics, and behavior, in a range of experimental model systems ranging from heterologous cells in culture, neurons generated from induced pluripotent stem (iPS) cells from human patients, and ex vivo and in vivo in animal models of human disease. The lab is particularly interested in the function of a prominent subtype of neuron known as the GABAergic inhibitory interneuron and the role of interneuron dysfunction as a cause of disease.
News from the Lab
Congrats, Ethan!
Ethan's appointment to Full Professor was approved by the Provost of the University of Pennsylvania, effective 2026. Congrats, Ethan!
Dravet Syndrome Foundation
Led by Zach Rosenthal, our Research Grant “Neuromodulation for Dravet Syndrome: Preclinical Validation of a Novel Therapeutic Mechanism ” has been approved for funding by Dravet Syndrome Foundation (DSF). This Grant will support Zach's work studying basic mechanisms...
2025 Society for Neuroscience Annual Meeting
Mia Sherer recently attended the 2025 Society for Neuroscience Annual Meeting. She presented a poster entitled "A Novel Mouse Model of SCN3A-Related Neurodevelopmental Disorder" that was very well attended and generated a lot of interest. She also delivered a short...