The goal of the Lab is to develop new treatments and work towards a cure for epilepsy and other neurodevelopmental disorders using a range of innovative approaches in experimental systems.
The Lab studies mechanisms of cerebral cortical circuit function and circuit dysfunction in neurodevelopmental disorders. Investigators in the lab use mouse and human genetics, electrophysiology, pharmacology, imaging, optogenetics, and behavior, in a range of experimental model systems ranging from heterologous cells in culture, neurons generated from induced pluripotent stem (iPS) cells from human patients, and ex vivo and in vivo in animal models of human disease. The lab is particularly interested in the function of a prominent subtype of neuron known as the GABAergic inhibitory interneuron and the role of interneuron dysfunction as a cause of disease.
News from the Lab
Congrats, Jerome!
Jerome Clatot has been appointed Research Assistant Professor in the Division of Neurology, Department of Pediatrics, here at CHOP. Jerome will remain a member of the lab and collaborate while continuing to develop his own research program. Congratulations to Jerome!
Congrats, Mia!
Mia Sherer was accepted to and is currently attending the prestigious Paris NeuroCourse "Optical Imaging and Electrophysiological Recording in Neuroscience" previously attended by Sophie L.
Congrats, Sophie L!
Sophie Liebergall's abstract entitled "Neocortical parvalbumin-expressing interneurons display progressive decreases in axonal action potential fidelity during sustained high-frequency firing" has been selected for a talk at the prestigioius Gordon Research Seminar...