Welcome to the Goldberg Lab

Studying the structure and function of cerebral cortical circuits and circuit dysfunction in epilepsy


The goal of the Lab is to develop new treatments and work towards a cure for epilepsy and other neurodevelopmental disorders using a range of innovative approaches in experimental systems.

The Lab studies mechanisms of cerebral cortical circuit function and circuit dysfunction in neurodevelopmental disorders. Investigators in the lab use mouse and human genetics, electrophysiology, pharmacology, imaging, optogenetics, and behavior, in a range of experimental model systems ranging from heterologous cells in culture, neurons generated from induced pluripotent stem (iPS) cells from human patients, and ex vivo and in vivo in animal models of human disease. The lab is particularly interested in the function of a prominent subtype of neuron known as the GABAergic inhibitory interneuron and the role of interneuron dysfunction as a cause of disease. 

News from the Lab

Congrats, Sarah!

Penn junior undergraduate Sarah Pham has been awarded a 2022 Louis H Castor M.D. Undergraduate Research Grant in the amount of $1,000 via the University of Pennsylvania's Center for Undergraduate Research and Fellowships (CURF) for her ongoing research project...

Congrats, Jade!

Congratulations to Postdoctoral Fellow Jade Feng on her poster acceptance to the Basic Science Poster Highlights Session at the American Epilepsy Society 2022 Annual Meeting in Nashville, TV, in December 2022. This poster session features the 40 best posters from over...

Congrats, Sophie!

Congratulations to MD-PhD student Sophie Liebergall for receiving a 2022 Trainee Professional Development Award from the Society for Neuroscience to fund her attendance to the 2022 Annual Society for Neuroscience meeting in San Diego, CA, in November 2022.