The goal of the Lab is to develop new treatments and work towards a cure for epilepsy and other neurodevelopmental disorders using a range of innovative approaches in experimental systems.
The Lab studies mechanisms of cerebral cortical circuit function and circuit dysfunction in neurodevelopmental disorders. Investigators in the lab use mouse and human genetics, electrophysiology, pharmacology, imaging, optogenetics, and behavior, in a range of experimental model systems ranging from heterologous cells in culture, neurons generated from induced pluripotent stem (iPS) cells from human patients, and ex vivo and in vivo in animal models of human disease. The lab is particularly interested in the function of a prominent subtype of neuron known as the GABAergic inhibitory interneuron and the role of interneuron dysfunction as a cause of disease.
News from the Lab
Congrats, Sophie!
Sophie Hill is being awarded the Brody Family Medical Trust Fund Fellowship in Incurable Diseases from The Philadelphia Foundation and The College of Physicians of Philadelphia. Congrats, Sophie!
Congrats, Laura!
Laura McGarry has received a 2-Year $150,000 Postdoctoral Research Award from the Eagles Autism Foundation! Congratulations to Laura!! This will support her continued work studying convergent and divergent mechanisms of epilepsy and autism spectrum disorder in Dravet...
Congrats, Sophie Liebergall!
Sophie Liebergall's paper is out in print!Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndromehttps://doi.org/10.1523/JNEUROSCI.1977-23.2024