The goal of the Lab is to develop new treatments and work towards a cure for epilepsy and other neurodevelopmental disorders using a range of innovative approaches in experimental systems.
The Lab studies mechanisms of cerebral cortical circuit function and circuit dysfunction in neurodevelopmental disorders. Investigators in the lab use mouse and human genetics, electrophysiology, pharmacology, imaging, optogenetics, and behavior, in a range of experimental model systems ranging from heterologous cells in culture, neurons generated from induced pluripotent stem (iPS) cells from human patients, and ex vivo and in vivo in animal models of human disease. The lab is particularly interested in the function of a prominent subtype of neuron known as the GABAergic inhibitory interneuron and the role of interneuron dysfunction as a cause of disease.
News from the Lab
Melody Cheng receives two awards
Congratulations to Melody Cheng for receiving the Ernest M. Brown, Jr. College Alumni Society Undergraduate Research Grant and the Frances Velay Women and Science Research Fellowship.
Joanna Mattis Published in eLife!
Congratulations to Mattis et al on their new paper in eLife! https://elifesciences.org/articles/69293
NIH NINDS R25 Award
Patrick Lawlor MD/PhD Child Neurology resident receives NIH NINDS R25 Award co-mentored by Ethan and Vijay Balasubramanian (Director of Penn Computational Neuroscience Initiative)