Welcome to the Goldberg Lab

Studying the structure and function of cerebral cortical circuits and circuit dysfunction in epilepsy


The goal of the Lab is to develop new treatments and work towards a cure for epilepsy and other neurodevelopmental disorders using a range of innovative approaches in experimental systems.

The Lab studies mechanisms of cerebral cortical circuit function and circuit dysfunction in neurodevelopmental disorders. Investigators in the lab use mouse and human genetics, electrophysiology, pharmacology, imaging, optogenetics, and behavior, in a range of experimental model systems ranging from heterologous cells in culture, neurons generated from induced pluripotent stem (iPS) cells from human patients, and ex vivo and in vivo in animal models of human disease. The lab is particularly interested in the function of a prominent subtype of neuron known as the GABAergic inhibitory interneuron and the role of interneuron dysfunction as a cause of disease. 

News from the Lab

Congrats, Evan!

Penn PGY-3 Neurology Resident and recent NIH NINDS R25 recipient Evan Rosenberg published the magnum opus from his PhD! Evan shows that cannabidiol (CBD ) blocks the effects of an endogenous lipid (LPI) at the receptor GPR55, preventing LPI-mediated effects at both...

Congrats, Sarah!

Penn junior undergraduate Sarah Pham has been awarded the Meyerhoff Summer Fellowship for Neuroscience Research for 2023. She will continue her work with our SCN3A Team to model SCN3A neurodevelopmental disorders in 3D. Congrats, Sarah!

Congrats, Laura and Evan!

Laura Mcgarry and Evan Rosenberg have both received an NINDS Research Education Programs for Residents and Fellows in Neurology and Neurosurgery (R25) Award. Congratulations!