Welcome to the Goldberg Lab

Studying the structure and function of cerebral cortical circuits and circuit dysfunction in epilepsy


The goal of the Lab is to develop new treatments and work towards a cure for epilepsy and other neurodevelopmental disorders using a range of innovative approaches in experimental systems.

The Lab studies mechanisms of cerebral cortical circuit function and circuit dysfunction in neurodevelopmental disorders. Investigators in the lab use mouse and human genetics, electrophysiology, pharmacology, imaging, optogenetics, and behavior, in a range of experimental model systems ranging from heterologous cells in culture, neurons generated from induced pluripotent stem (iPS) cells from human patients, and ex vivo and in vivo in animal models of human disease. The lab is particularly interested in the function of a prominent subtype of neuron known as the GABAergic inhibitory interneuron and the role of interneuron dysfunction as a cause of disease. 

News from the Lab

Summer Research!

Sarah Pham, Melody Cheng, and Yerahm Hong, will be presenting posters on their summer research at the Penn Center for Undergraduate Research (CURF) 2023 Fall Research Expo on Monday, September 18, from 5:00-8:00 PM. Congrats, Melody and Sarah!

Congrats, Sarah!

Sarah Pham has received a Research Supplement to Promote Diversity from the National Institute of Neurological Disorders and Stroke (NINDS) entitled "Assessing mechanisms of brain malformation in SCN3A encephalopathy using stem cell-based models." This is a Supplement...

Congrats, Evan!

Penn PGY-3 Neurology Resident and recent NIH NINDS R25 recipient Evan Rosenberg published the magnum opus from his PhD! Evan shows that cannabidiol (CBD ) blocks the effects of an endogenous lipid (LPI) at the receptor GPR55, preventing LPI-mediated effects at both...