The goal of the Lab is to develop new treatments and work towards a cure for epilepsy and other neurodevelopmental disorders using a range of innovative approaches in experimental systems.
The Lab studies mechanisms of cerebral cortical circuit function and circuit dysfunction in neurodevelopmental disorders. Investigators in the lab use mouse and human genetics, electrophysiology, pharmacology, imaging, optogenetics, and behavior, in a range of experimental model systems ranging from heterologous cells in culture, neurons generated from induced pluripotent stem (iPS) cells from human patients, and ex vivo and in vivo in animal models of human disease. The lab is particularly interested in the function of a prominent subtype of neuron known as the GABAergic inhibitory interneuron and the role of interneuron dysfunction as a cause of disease.
News from the Lab
Yerahm Hong has been selected as a Rachleff Scholar in Engineering. This program will support research in the lab next summer. Congrats, Yerahm!
Sophie Hill is the recipient of the 2023 Holt Family Epilepsy Neurogenetics Fellowship, becoming our second annual Fellowship recipient. Congratulations, Sophie!
Congrats to Guojie, Julie, and Jerome's paper entitled "Targeted blockade of aberrant sodium current in an iPSC-derived neuron model of SCN3A encephalopathy" for being accepted to the journal Brain (Impact Factor 14.5).